What's New? © 2020 MedPage Today, LLC. Posted: 20 Feb 2020 12:00 AM PST. Post-Therapy Lung Cancer Surveillance: Recent Research Context - MedPage Today Posted: 07 Feb 2020 05:33 AM PST As curative-intent lung cancer therapy has become more successful, there is a need for standardized post-treatment surveillance and a common multimodality surveillance paradigm. Arimidex Prevents First Breast Cancers-SAN ANTONIO -- Anastrozole (Arimidex) reduced the risk of breast cancer by 53% in high-risk postmenopausal women, a primary prevention trial showed. The findings highlighted the differences in the natural history of interval-detected cancers, as well as "inadequacies in current breast cancer screening practice," reported Saroj Niraula, MD, of the University of Manitoba in Winnipeg, and colleagues in JAMA Open Network. Read the full story at MedPage Today. "The consensus group agreed that CPM should be … Women with the common Luminal A subtype of breast cancer get no benefit from chemotherapy even if they have large tumors and positive nodes and no hormonal therapy. According to the American Cancer Society, the five-year survival rate for breast cancer if diagnosed as stage 1 to stage 3 is between 100 percent and 72 percent. Brain metastases are one of the most common and difficult-to-treat occurrences in metastatic breast cancer. The study had support from the Canadian Breast Cancer Foundation, the IM Daehnfeldt Foundation, and the Danish Research Council. 21 (July 20, 2020) 2454-2462.. Researchers at Washington University School of Medicine in St. Louis found that every drink—whether beer, wine, or liquor—a young woman consumes daily before her first pregnancy puts her at a nearly 15 percent greater risk of developing proliferative benign breast disease , a noncancerous breast condition linked to breast cancer. "We know that luminal A breast cancers have a very good prognosis," commented Anees Chagpar, MD, of Yale Cancer Center in New Haven, Conn., who was not part of the study. In order to have the best experience on our sites, we recommend that users utilize the latest available versions of web browsers and assistive technology. He joined MedPage Today in 2007. Our efforts are ongoing. "Chemotherapy kills fast-growing cells," she told MedPage Today, "so the whole concept of chemotherapy is exactly the opposite of what luminal A cells are.". The findings came from a phase III randomized trial involving 266 patients with a median age of 73.5. The analysis of three SEER registries spanning 1973-2009, 1992-2009, and 2000-2009 showed an increase from 1.53 to 2.90 per 100,000 in incidence of breast cancer … "The literature still warns women that if you get on an airplane you're either going to develop lymphedema or it will worsen," she said, noting that it was thought to result from extra demand on the lymphatic system from cabin pressure changes. Adjuvant CDK4/6 Inhibitor Thwarts Recurrence. Neilsen TO, et al "High risk premenopausal Luminal A breast cancer patients derive no benefit from adjuvant chemotherapy: results from DBCG77B randomized trial". SAN ANTONIO -- Premenopausal women with a luminal A breast cancer get no long-term survival benefit from adjuvant chemotherapy, a researcher said here. Forum; FAQ; Calendar; Forum Actions. Recent Developments in Breast Cancer - MedPage Today Recent Developments in Breast Cancer MedPage Today Recent Developments in Breast Cancer - MedPage Today Read More. Published On: July 5, 2016 Shared by Georgina Perez. Meeting Coverage > SABCS Some Breast Cancer Patients Can Skip Chemo-Women with luminal A disease derive no benefit. The FDA denied a petition by two tobacco companies to ease up on the warnings around smokeless tobacco. share to linkedin. Breast cancer isn’t what it was 20 years ago. In women under 45, breast cancer is more common in Black women than white women. Thankfully, she listened to her husband. They are found in 10% to 30% of patients. A randomized trial showed a 4.3% absolute difference in disease-free survival (DFS) with trastuzumab (Herceptin) alone versus trastuzumab plus chemotherapy. MedPage: APHINITY and ATEMPT: Treating Early-Stage HER2+ Breast Cancer. The 48-year-old actress is best known for her roles in the original "Beverly Hills, 90210" and "Charmed." Beyond CDK4/6 Inhibitors for HR-Positive Breast Cancer - MedPage Today Posted: 11 Mar 2020 12:31 PM PDT MIAMI BEACH -- As clinical investigation pushes the envelope with CDK4/6 inhibitors, multiple lines of research examine "what's next" when hormone receptor-positive breast cancer progresses or develops resistance. Email This BlogThis! Emphasizing that preliminary nature of the trial, the authors point out that positive early data previously reported from the phase III KEYNOTE 522 trial provided strong supporting evidence for the strategy of combining immunotherapy with preoperative chemotherapy. But evaluating the effect of chemotherapy on breast cancer today is a difficult chore, since the benefit is so widely established that a placebo arm would be considered unethical, Nielsen noted. We also rely on our community to tell us when they experience an issue with any of our sites, and we give consideration to all feedback that is provided to us. North American Correspondent, MedPage Today Prespecified statistical considerations for noninferiority established an upper confidence limit of 1.69. By Charles Bankhead, Staff Writer, MedPage Today. Share to Twitter Share to Facebook Share to Pinterest. In luminal A disease, the hazard ratio for disease-free survival was 1.07, with a 95% confidence interval from 0.53 to 2.14, and was nonsignificant, Patients with non-luminal A subtypes had a hazard ratio of 0.50, with a 95% confidence interval from 0.38 to 0.66, favoring chemo. They are found in 10% to 30% of patients. Breast cancer survivor Makieba Hatton and cardiologist Dr. Susan Gilchrist discuss on the 3rd hour of TODAY how the Healthy Heart Program is combating risk factors to keep patients healthy. MedPage Today, New York, New York. MedPage Today: Revisiting Neoadjuvant Hormones for ER+ Breast Cancer. Neoadjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer achieved response rates similar to those obtained with combination chemotherapy but with less toxicity, pooled … "[Jolie] h ad a specific mutation that meant she had an 85% chance of having breast cancer by the age of 75 or so," he said. Women with high-risk breast cancer with non-luminal A disease given chemotherapy had a significant improvement in 10-year disease-free survival compared with those on placebo. Ongoing studies are looking at ways to enhance current breast cancer screening options. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal. SABCS: A Call to Scrap Anthracyclines for Breast Cancer-by Michael Smith, North American Correspondent, MedPage Today 2007-12-13 share to facebook. But the benefit was only seen among women with non-luminal A disease, even though all participants had node-positive disease and large tumors, Nielsen told reporters at the 38th San Antonio Breast Cancer Symposium. Source Reference: Neilsen TO, et al "High risk premenopausal Luminal A breast cancer patients derive no benefit from adjuvant chemotherapy: results from DBCG77B randomized trial" SABCS 2015; Abstract S1-08. Most women with newly diagnosed unilateral breast cancer do not benefit from contr alateral prophylactic mastectomy (CPM) and should not routinely undergo the procedure, accord ing to a consensus statement from the American Society of Breast Surgeons (ASBrS). ASCO Roundtable: More Breast Cancer Highlights - Medpage Today "The results indicate the prevention of early recurrence and a clinically meaningful reduction in the risk of distant recurrence.". Charles Bankhead is senior editor for oncology and also covers urology, dermatology, and ophthalmology. Start here to find information on breast cancer treatment, causes and prevention, screening, research, and statistics. Home » MedPage: APHINITY and ATEMPT: Treating Early-Stage HER2+ Breast Cancer. We will make all reasonable efforts to address your concerns. The pCR rate increased from 17% with chemotherapy alone to 44% in women who also received pembrolizumab (Keytruda) prior to surgery. A technically negative clinical trial nonetheless made a case for omitting chemotherapy from treatment for selected older patients with early-stage HER2-positive breast cancer, Japanese investigators suggested in the Journal of Clinical Oncology. But breast cancer researchers, radiologists and primary care physicians contacted by ABC News overwhelmingly agreed that the benefits of mammographic screening in women ages 40 to … The analysis included 69,025 women who underwent a total of 212,579 mammograms during 2004 to 2010. We are adding another line of chemotherapy with really good response rates," she told MedPage Today. "We observed an overall survival of 95% in both arms of the trial," he told MedPage Today at the 2017 San Antonio Breast Cancer Symposium. Published: Sep 14, 2013. share … © 2020 MedPage Today, LLC. Three-Drug Breast Cancer Regimen Slows Progression-Appears to overcome 'cross talk' that leads to resistance. North American Correspondent, MedPage Today. "The clinical benefit here confirms the use of sacituzumab govitecan as a standard therapy for patients with pretreated metastatic triple-negative breast cancer," Bardia said. Chemotherapy was associated with a 70.6% incidence of grade 3/4 adverse events, and almost all types and grades of adverse events occurred more often in the chemotherapy arm. Of 1,687 breast cancers diagnosed, 705 were screen detected, 206 were interval detected (within 2 years of a normal mammogram), 275 involved noncompliant patients (>2 years since last mammogram), and 501 involved women outside the screening program. In fact, the presence of the noncancerous breast lesions raises a woman's risk of breast cancer by up to 500 percent. As compared with cancers identified during screening, interval cancers had significantly higher odds ratios (OR) for high-grade disease (OR 6.33 for grade III vs grade 1, 95% CI 3.73-10.75, P<0.001) and negative estrogen-receptor status (OR 2.88, 95% CI 2.01-4.13, P<0.001). 197K likes. The primary endpoint was iDFS. by Michael Smith, North American Correspondent, MedPage Today … Escalating neoadjuvant therapy, with the addition of a PD-1 inhibitor to chemotherapy, more than doubled the rate of pathologic complete response (pCR) in women with early-stage breast cancer, results of a phase II clinical trial showed. It Is. Action Points. The bottom line of the study was a clear benefit in 10-year disease-free survival for the chemo, Nielsen said. Posted by Blog Gana at 7:26 PM. by Median progression-free survival increased from 1.7 months with chemotherapy to 5.6 months with the ADC. An RMST analysis for relapse-free survival (95.3% with chemotherapy, 92.4% without) yielded a 3-year difference of -0.41 months. — Adjuvant CDK4/6 inhibition, immunotherapy and pCR, ADC for metastatic TNBC. "It's not surprising that they don't respond to chemotherapy," she told MedPage Today. Nonetheless, he told MedPage Today, it suggests that patients with luminal A tumors and their doctors should think carefully about whether to use chemotherapy, especially since the modern treatment landscape has options -- such as endocrine treatment -- that were not available when the study was conducted. If at any time you have questions or concerns regarding accessibility, or experience technical issues, please contact us at accessibility@everydayhealth.com. The trial, involving 529 patients with TNBC from seven countries, showed that treatment with sacituzumab govitecan led to a higher response rate (35% vs 5%) and higher clinical benefit rate (45% vs 9%). Overall, Black women are more likely to die of breast cancer. PMID: 32255711 Online Tool Refines Individual Risks in Breast Cancer Medpage Today 20:19 13-Dec-20. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our users and subscribers. Kaklamani disclosed a relationship with Genomic Health. We strive to make all of our content accessible to all users and continually work to improve various features of our sites. The past year brought the breast cancer community a CDK inhibitor for early-setting disease, the combination of a PD-1 inhibitor and preoperative chemotherapy in advanced disease, trastuzumab monotherapy for some older patients, third-line antibody-drug conjugate (ADC) therapy instead of chemo, and data on the risks posed by interval-detected breast cancers. Recent Developments in Breast Cancer - MedPage Today Recent Developments in Breast Cancer MedPage Today Recent Developments in Breast Cancer - MedPage Today Read More. Clinical Challenges: HR+/HER2- Advanced Breast Cancer and CDK4/6 Inhibitors - MedPage Today Posted: 25 Jun 2020 12:00 AM PDT The development and approval of cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors have been called game-changers in the treatment of patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer. In the study, Tripathy and colleagues administered ribociclib to 335 women; placebo was administered to 337 women. But once the cancer … Researchers with no access to the clinical database conducted the biomarker scoring, which classified 165 samples as luminal A, 319 as luminal B, 58 as HER2-enriched, and 91 as triple negative. (MedPage Today) -- Brain metastases are one of the most common and difficult-to-treat occurrences in metastatic breast cancer. The average American woman has a 12% chance of gett ing breast cancer." Email This BlogThis! Email Residual disease burden also declined in patients who received the add-on immunotherapy, reported Rita Nanda, MD, of the University of Chicago, and colleagues JAMA Oncology. Interested in information on breast cancer or some other oncology-specific topic? New cancer diagnoses have fallen far short of expectations in the U.S. during the first peak of the COVID-19 pandemic, reported Harvey Kaufman, MD, of Quest Diagnostics, in JAMA Network Open. Initial treatments for brain metastases include locally directed […] Women with breast cancer appear to experience deficits in working ... Another step in fight against Another step in fight against 'Chemo Brain' May Start Before Breast Cancer Tx - MedPage Today Among patients with triple-negative breast cancer (TNBC), pCR occurred in 6o% of patients treated with pembrolizumab and chemotherapy. Invasive disease events occurred in 134 women receiving just chemotherapy and 130 women getting chemotherapy plus trastuzumab during the 5 years of the study, Fehrenbacher reported at an SABCS press conference. "It's not surprising that they don't respond to chemotherapy," she told MedPage Today. “I was taken entirely by surprise. "Abemaciclib is the first CDK inhibitor to show a significant improvement in the early breast cancer setting, when combined with endocrine therapy, as compared with endocrine therapy alone," Stephen R. D. Johnston, MD, of the Royal Marsden Hospital in London, said during the European Society for Medical Oncology (ESMO) virtual congress. They are found in 10% to 30% of patients. There's a growing need to understand what therapies are appropriate for which patients, Nielsen said, and molecular subtypes like luminal A are beginning to play an important role in treatment decisions. FDA: Smokeless Tobacco Warning Stays. Risk for Breast Cancer Low with Testosterone Tx. If at any time you have questions or concerns regarding accessibility, or experience technical issues, please contact us at accessibility@everydayhealth.com. "In light of the lower toxicity and more favorable HRQoL [health-related quality of life] profile, trastuzumab monotherapy can be considered as an adjuvant therapy option for selected older patients," Masataka Sawaki, MD, PhD, of Aichi Cancer Center Hospital in Nagoya, and colleagues concluded. Ominous Nature of Interval-Detected Cancers Affirmed. Home » MedPage Today: Revisiting Neoadjuvant Hormones for ER+ Breast Cancer. Indeed, the finding is almost no surprise, outside experts said, since the markers that are used to define luminal A disease are also known -- in combination -- to be signs of a favorable prognosis as defined in modern molecular tests. Posted by Blog Gana at 5:01 PM. Nielsen disclosed relationships with Bioclassifier and NanoString Technologies. Meaningful reduction in the risk of distant recurrence. `` of 1.36 ( 95 CI... 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