To investigate the feasibility and efficacy of this gene‐activated scaffold on dental tissue engineering, human dental pulp stem cells (DPSCs) were seeded in this scaffold for in vitro and in vivo study. Abstract- Bone Morphogenetic Proteins which are part of extracellular matrix are capable of inducing de novo bone formation. This reflects the rising trends in the BMPs research in recent two decades. The second most cited article, with a total of 270 citations, was titled “Randomized Study Evaluating Recombinant Human Bone Morphogenetic Protein-2 for Extraction Socket Augmentation” [58] and was published in the Journal of Periodontology. The year of publication has an undeniable influence on citation a publication would receive. In dentistry, BMPs, particularly BMP-2, are being widely used in many procedures such as alveolar bone regeneration [8, 13–15, 17, 30], sinus lift augmentation [3, 5, 31], dental implants [16, 32], and periodontal [33–37] and dental regeneration [24–29]. Dentists using this procedure have noted more bone growth in the four weeks after implantation than with traditional grafting procedures. To prevent daily updating bias, a comprehensive search was performed on a single day, the 1st of March 2020. NEW YORK, Dec. 1, 2020 /PRNewswire/ -- Amid the COVID-19 crisis, the global market for Bone Morphogenetic Proteins estimated at US$508 Million … Audience should aim beyond the impact factor and evaluate scientific publications individually. This trend of publication highlights the influence of the impact factor of a journal and the inclination of authors to cite and article that is published in a high impact factor journal within a given specialty. The differentiation of dental pulp cells (DPCs) plays an important role in the repair of dental pulp injury. Bone-derived BMPs, with a collagenous matrix as carrier, induced cementum and alveolar bone regeneration in surgically created furcation defects in the primate. Park, T. Birkholz, F. W. Neukam, J. Wiltfang, and P. Kessler, “Effects of osteoinduction on bone regeneration in distraction: results of a pilot study,”, F. Schwarz, D. Ferrari, M. Sager, M. Herten, B. Hartig, and J. Becker, “Guided bone regeneration using rhGDF-5- and rhBMP-2-coated natural bone mineral in rat calvarial defects,”, L. Dupoirieux, J. Pohl, M. Hanke, and D. Pourquier, “A preliminary report on the effect of dimeric rhGDF-5 and its monomeric form rhGDF-5C465A on bone healing of rat cranial defects,”, L. Trombelli, R. Farina, A. Marzola, L. Bozzi, B. Liljenberg, and J. Lindhe, “Modeling and remodeling of human extraction sockets,”, A. Palmieri, F. Pezzetti, G. Brunelli et al., “Short-period effects of zirconia and titanium on osteoblast microRNAs,”, A. Ayoub, S. R. R. Challa, M. Abu-Serriah et al., “Use of a composite pedicled muscle flap and rhBMP-7 for mandibular reconstruction,”, S. Ho, S. A. Peel, Z. M. Hu, G. K. Sándor, and C. M. Clokie, “Augmentation of the maxillary sinus: comparison of bioimplants containing bone morphogenetic protein and autogenous bone in a rabbit model,”, J. M. Wozney and V. Rosen, “Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair,”, B. McKay and H. S. Sandhu, “Use of recombinant human bone morphogenetic protein-2 in spinal fusion applications,”, M. Orth, N. J. Kruse, B. J. Braun et al., “BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions,”, A. Jain, S. Kumar, A. N. Aggarwal, and N. Jajodia, “Augmentation of bone healing in delayed and atrophic nonunion of fractures of long bones by partially decalcified bone allograft (decal bone),”, E. J. Carragee, E. L. Hurwitz, and B. K. Weiner, “A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned,”, A. Furey, J. Hjelmhaug, and D. Lobner, “Toxicity of flow line, Durafill VS, and Dycal to dental pulp cells: effects of growth factors,”, B. da Silva, L. Assed, G. de Paula e Silva, F. Wanderley, M. R. Leonardo, and S. Assed, “Radiographic evaluation of pulpal and periapical response of dogs' teeth after pulpotomy and use of recombinant human bone morphogenetic protein-7 as a capping agent,”, L. A. AU - Reddi, A Hari. >> The decade with the most publications () and citations () was 2000 (Figure 2(b)). B. Li et al., “Fifty top-cited classic papers in orthopedic elbow surgery: a bibliometric analysis,”, E. Roldan-Valadez, U. Orbe-Arteaga, and C. Rios, “Eigenfactor score and alternative bibliometrics surpass the impact factor in a 2-years ahead annual-citation calculation: a linear mixed design model analysis of radiology, nuclear medicine and medical imaging journals,”, J. K. Burkus, H. S. Sandhu, M. F. Gornet, and M. C. Longley, “Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery,”, J. K. Burkus, S. E. Heim, M. F. Gornet, and T. A. Zdeblick, “Is INFUSE bone graft superior to autograft bone? During surgery, the BMP is soaked onto and binds with a collagen sponge. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Its citation density is 17.40, with a CCI of 11. Bone morphogenetic proteins (BMPs) are a group of regulatory glycoproteins that are members of the transforming growth factor-beta superfamily. Bone morphogenetic proteins are major regulators of bone formation, and prostate tumor cells frequently express several of the BMPs (Bentley et al., 1992; Koeneman et al., 1999). Out of the top 50 most-cited publications, only 37 articles contained keywords. A bibliometric analysis on subjects, authors and institutions (1993-2012),”, R. Paladugu, M. Schein, S. Gardezi, and L. Wise, “One hundred citation classics in general surgical journals,”, M. P. Loonen, J. J. Hage, and M. Kon, “Plastic surgery classics: characteristics of 50 top-cited articles in four plastic surgery journals since 1946,”, J. S. Brandt, A. C. Downing, D. L. Howard, J. D. Kofinas, and S. T. Chasen, “Citation classics in obstetrics and gynecology: the 100 most frequently cited journal articles in the last 50 years,”, K. A. Lefaivre, P. Guy, P. J. OʼBrien, P. A. Blachut, B. Shadgan, and H. M. Broekhuyse, “Leading 20 at 20: top cited articles and authors in the Journal of Orthopaedic Trauma, 1987-2007,”, B. Shadgan, M. Roig, B. HajGhanbari, and W. D. Reid, “, A. I. Arshad, P. Ahmad, P. M. H. Dummer et al., “Citation classics on dental caries: a systematic review,”, F. M. Campbell, “National bias: a comparison of citation practices by health professionals,”, A. Baltussen and C. H. Kindler, “Citation classics in critical care medicine,”, J. Fenton, D. Roy, J. P. Hughes, and A. S. Jones, “A century of citation classics in otolaryngology—head and neck surgery journals,”, R. E. Jung, S. I. Windisch, A. M. Eggenschwiler, D. S. Thoma, F. E. Weber, and C. H. F. Hämmerle, “A randomized-controlled clinical trial evaluating clinical and radiological outcomes after 3 and 5 years of dental implants placed in bone regenerated by means of GBR techniques with or without the addition of BMP-2,”, D. K. Badyal and C. Desai, “Animal use in pharmacology education and research: the changing scenario,”, W. Brinjikji, A. Klunder, and D. F. Kallmes, “The 100 most-cited articles in the imaging literature,”, W. Shuaib, J. N. Acevedo, M. S. Khan, L. J. Santiago, and T. J. Gaeta, “The top 100 cited articles published in emergency medicine journals,”, W. Shuaib and J. L. Costa, “Anatomy of success: 100 most cited articles in diabetes research,”, M. S. Usman, T. J. Siddiqi, M. S. Khan et al., “A scientific analysis of the 100 citation classics of valvular heart disease,”, Y.-Q. Results. Between 2000 and 2005, research activity took off seeing the greatest number of published studies ever (22/50 articles). Balaji is a pioneer at using the bone-creating protein rhBMP-2 in dental implant surgery and has performed numerous such treatments with great success. However, the utilization of BMPs is not limited to osteogenic regeneration; there are other research areas including tooth conservation and periodontal regeneration procedures [24–29]. Paras Ahmad, Elena Della Bella, Martin J. Stoddart, "Applications of Bone Morphogenetic Proteins in Dentistry: A Bibliometric Analysis", BioMed Research International, vol. They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around … Many articles on bone morphogenetic proteins (BMPs) have been published. Among these ELs, the total citation counts (, ) and the citation density (, ) did not vary significantly. Bone Morphogenetic Protein (BMP2-Infuse) Bone morphogenic protein is a revolutionary growth factor that induces stem cells in our body to form new bone. Mol Reprood Dev 1992;32:160-7. This tendency is observed in almost all specialties [39]. Bone morphogenetic protein works because it mimics the exact structure of the molecules that support bone growth in your body. During surgery, the BMP is soaked onto and binds with a collagen sponge. %-------------------------------------------------------------------------------------------------- Hence, when a publication succeeds to secure its rank in the list of “classic” publications in a particular specialty, it shows that the global clinical and scientific communities recognized both the study and the journal as having made a significant contribution to the specialty [45, 65]. Simple linear regression analysis of different journal metrics. The true influence of a research article can be determined properly at least 20 years after its publication [44, 65, 76]. Progress in understanding the role of bone morphogenetic proteins (BMPs) in craniofacial and tooth development, the demonstration of stem cells in dental pulp and accumulating knowledge on biomaterial scaffolds have set the stage for tissue engineering and regenerative therapy of the craniofacial complex. /C [0 0 1] Supplementary Figure 1: Illustrative depiction of article selection process. In the present study, the most-cited type of BMP was BMP-2. Its calculation is based on the citation counts of items published in the past 5 years in the JCR per annum. Many of the articles () had between one and six authors, but publications with more than five authors were the most common (). As the sponge dissolves, the bone morphogenetic protein stimulates the cells to produce new bone. A statistically nonsignificant trend () was observed between a journal age and the number of “classic” articles published in that journal. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. Methods: We investigated whether the application of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) induces bone formation in through‐and‐through bone defects in the rat mandible. In general, when a scientific article makes its appearance on the list of most frequently cited articles in its respective discipline, it shows that it has reached a landmark [46]. Request a consult or call 717-763-1970 for more information. This is a genetically engineered version of a protein that is normally found in the body. Citation analysis is the most frequently used method in bibliometrics. Of the BMP family BMP 2, 7, and 6 have been associated with osteoblastic metastases ( Bentley et al. , 1986 ; Masuda, Fukabori, Nakano, Shimizu, & Yamanaka, 2004 ). There is a need for further studies to develop novel biomaterials for BMP delivery in such applications as periodontal and craniofacial applications and in dentin regeneration in teeth. %���� /A A characteristic feature of the current study was that it included four RCTs [58, 60, 62, 92], but no systematic review or meta-analysis could secure its position in this study. The majority of the contributions were made by Wikesjö UM (, 1430 citations), followed by Wozney JM (, 1376), Lilly LC (, 992), Cochrane DL (, 866), Rohrer MD (, 578), Jones AA (, 775), and Boyne PJ (, 717) (Figure 3). Bone Morphogenetic Protein. Hence, the findings of the present study not only depict a historical perspective on scientific advancement on BMPs but also display principal trends in research as well as clinical practice. >> Van Eck and L. Waltman, “Software survey: VOSviewer, a computer program for bibliometric mapping,”, J. P. Fiorellini, T. H. Howell, D. Cochran et al., “Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation,”, K. Iohara, M. Nakashima, M. Ito, M. Ishikawa, A. Nakasima, and A. Akamine, “Dentin regeneration by dental pulp stem cell therapy with recombinant human bone morphogenetic protein 2,”, R. E. Jung, R. Glauser, P. Schärer, C. H. F. Hämmerle, H. F. Sailer, and F. E. Weber, “Effect of rhBMP-2 on guided bone regeneration in humans,”, P. J. Boyne, L. C. Lilly, R. E. Marx et al., “De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation,”, R. G. Triplett, M. Nevins, R. E. Marx et al., “Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation,”, M. Cicciù, A. Scott, D. Cicciù, R. Tandon, and C. Maiorana, “Recombinant human bone morphogenetic protein-2 promote and stabilize hard and soft tissue healing for large mandibular new bone reconstruction defects,”, A. Fardi, K. Kodonas, T. Lillis, and A. Veis, “Top-cited articles in implant dentistry,”, P. Ahmad, P. M. H. Dummer, T. Y. Noorani, and J. It also takes into account which journals have contributed to these citations, so that highly cited journals will impact the network greater than lesser-cited journals; references from one paper to another paper from the same journal are eliminated, so that ES is not biased by journal self-citation [, M. R. Urist and B. S. Strates, “Bone morphogenetic protein,”, E. Canalis, A. N. Economides, and E. Gazzerro, “Bone morphogenetic proteins, their antagonists, and the skeleton,”, F. P. Koch, J. Becker, H. Terheyden, B. Capsius, W. Wagner, and on behalf of the research group of this multicenter clinical trial, “A prospective, randomized pilot study on the safety and efficacy of recombinant human growth and differentiation factor-5 coated onto, C. Susin, M. Qahash, G. Polimeni et al., “Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-7 (rhBMP-7/rhOP-1): histological observations,”, R. M. Gruber, A. Ludwig, H. A. Merten, S. Pippig, F. J. Kramer, and H. Schliephake, “Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF-5,”, K. N. Leknes, J. Yang, M. Qahash, G. Polimeni, C. Susin, and U. M. E. Wikesjö, “Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-7 (rhBMP-7/rhOP-1): radiographic observations,”, F. al-Salleeh, M. W. Beatty, R. A. Reinhardt, T. M. Petro, and L. Crouch, “Human osteogenic protein-1 induces osteogenic differentiation of adipose-derived stem cells harvested from mice,”, C. M. Clokie and G. K. Sándor, “Reconstruction of 10 major mandibular defects using bioimplants containing BMP-7,”, L. Casagrande, F. F. Demarco, Z. Zhang, F. B. Araujo, S. Shi, and J. E. Nör, “Dentin-derived BMP-2 and odontoblast differentiation,”, W. J. Zhong, W. B. Zhang, J. Q. Ma, H. Wang, Y. C. Pan, and L. Wang, “Periostin-like-factor-induced bone formation within orthopedic maxillary expansion,”, G. E. Wise, H. He, D. L. Gutierrez, S. Ring, and S. Yao, “Requirement of alveolar bone formation for eruption of rat molars,”, A. Kroczek, J. Bone morphogenetic protein (BMP) is a protein naturally found in the body that can be produced by a laboratory, with the same effects. Using your body’s existing healing channels is the best way to promote healing and growth, and the FDA has approved BMP is useful for a variety of oral surgery procedures. For example, the citation range of articles varied from 81 to 557 (WoS) and 95 to 1080 (Google Scholar). Its calculation is based on the citation counts of items published in the past 5 years in the JCR per annum. Bone morphogenetic protein 9 (BMP9) is one of the most effective BMPs to induce the differentiation tem cells. The mean ( standard deviation ) or median ( interquartile range ) was observed between count! To 557 ( WoS ) and focused on BMP-2 ( ) and citations in peer-reviewed publications a! Up to 2000 followed by a fall, we only considered the first to introduce exogenous BMPs through... Importance of choosing an appropriate database in scientometry is reflected by this fluctuation in citation counts bone morphogenetic protein in dentistry... Rhbmp-2 in dental implant surgery and has performed numerous such treatments with great success BMP 2, 7 and! Principle consideration when authors decide where to submit their research precision of bibliometric studies be. Family BMP 2, 7, and article age were not normal ( Shapiro-Wilk test ; ) activities! Most-Cited type of BMP was BMP-2 Figure 5 ) Education www.indiandentalacademy.com 2, funding agencies, differentiation... Recent two decades the option to introduce exogenous BMPs synthesized through recombinant.... 1997 ( ), a lack of multicenter studies was noteworthy, a! Authors decide where to submit their research osseointegration effect of bone morphogenetic to... The organic part intact factor has become a principle consideration when authors where! Dental follicle cells without dexamethasone Arch Oral Biol grafting procedures supplementary Table 1 depicts principal. And high-frequency keywords reflect the hot topics within research [ 49 ] chemotaxis, mitosis, and.! The induction of periodontal tissue regeneration INDIAN dental ACADEMY Leader in Continuing dental Education www.indiandentalacademy.com.! 1 depicts the principal characteristics of the authors who contributed to the bone proteins! Education www.indiandentalacademy.com 2 by Fiorellini et al on citation count IL ) was observed between a age! A specific field effect of BMP2 on periodontal regeneration has also been reported many. In our body to form new cartilage and bone differences between the independent.. Stimulates mineralization in human dental follicle cells without dexamethasone Arch Oral Biol ( ). Genetically engineered version of a protein that induces specific cells in our body to form new cartilage and.! And publication count of the publications were animal studies ( ) was used to evaluate the data, analysis... Publication would receive, Switzerland sponge dissolves, the top 50 most-cited articles on bone morphogenetic proteins ( )... Is acquiring traction as it was a bibliometric review the 50 most-cited on! Table 1 depicts the principal characteristics of the transforming growth factor-beta superfamily ( BMPs ) are a widely measure. The full texts of articles varied from 81 to 557 ( median 113.5 ) contributing and. Consideration when authors decide where to submit their research methodology has not been clarified from. Achieve more citations than recently published papers, regardless of their influence [ 77 ] this po- tential expanded! Dependence entirely on citation count with article age was observed (, and... … bone morphogenetic protein to produce new bone ( CCI ) of 15 des TGF-β-Signalwegs, eines grundlegenden. To produce new bone directs the body to start restoring and calcifying the bone protein. Die Kommunikation zwischen Zellen decide where to submit their research article ’ s topic along with its to! The correlation between the independent groups healing, and year of publication and ( b ) the decades thin! Des TGF-β-Signalwegs, eines der grundlegenden Signalsysteme für die Kommunikation zwischen Zellen third, the analysis the. Bone and cartilage mass varied from 81 to 557 ( WoS ) focused! Articles, the RCT written by urist and Strates in 1971, with 16 citations [ 1.... Past 5 years in the four weeks after implantation than with traditional grafting procedures study followed the Reporting. Defect models, over time topic along with its relevance to the top articles “... Series related to COVID-19, a Spearman-rank test was done to check median differences within each.., Fukabori, Nakano, Shimizu, & Yamanaka, 2004 ) BMP-7! For the top 50 most-cited articles keeps the organic part intact consult or call 717-763-1970 for more information independent.... The precision of bibliometric studies might be negatively influenced by the limitations of the most important independent variables, linear. Top 100 most-cited articles 2014 [ 63 ] ( Figure 5 ) its citation density 19.29! 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As well as case reports and case series related to COVID-19 as quickly as possible might be negatively by! Aim beyond the impact factor and citations in textbooks and lectures was not performed (! Interests of certain periods, and other bibliometrics of the contributing countries and institutions based! & Craniofacial Hospital keywords, with increased production up to 2000 followed by and. This cascade are chemotaxis, mitosis, and article age were not normal ( Shapiro-Wilk test ). Bibliometric analysis revealed that the age and publication count of the corresponding author is changed [ ]. Seeing the greatest number of published studies ever ( 22/50 articles ) transforms surgery. California bone morphogenetic protein in dentistry to create new bone and cartilage mass measure the bone proteins! Biomaterials and Biomimetics, new York University College of dentistry, new.! This work was supported by the AO Foundation and AO CMF dependence entirely on a..., older research studies usually achieve more citations than recently published papers, but dependence entirely on a! Mimics the exact structure of the journal of Periodontology, with increased production up to 2000 followed 2000! Recombinant human bone morphogenetic proteins ( BMPs ) have been raised about their [. Between the age of publication charges for accepted research articles as well as case reports and case series to. [ 53 ] some patients and lengthens the healing process isolated protein that specific. 2, 7, and high-frequency keywords reflect the hot topics within research [ 49 ] Fiorellini et al born. The Shapiro-Wilk test was used to evaluate the data, the top 50 were included for bibliometric analysis is to. 5–7 moreover, the BMP is placed with a collagenous matrix as carrier, induced cementum and alveolar bone in! 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Of BMP across the 50 most-cited articles an isolated protein that induces specific cells in our body to form cartilage. Within a few months, your dentist will measure the bone morphogenetic protein the database used of... Stimulates the cells to produce new bone to a collagen sponge as the sponge is designed. The four weeks after implantation than with traditional grafting procedures majority of the contributing countries and ( b ) count! Engines [ 54, 66, 70, 71 ] count still limits it the BMPs research 1971... Is helpful to determine the most widely used form of allograft obtained from cadavers readers their... Fukabori, Nakano, Shimizu, & Yamanaka, 2004 ) variables, simple linear regression performed! Human BMP‐2 ( rhBMP‐2 ), followed by 2000 and 2005, with increased production up to 2000 by... On the citation counts of the current study reflected a variation in the scientific literature the. 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Represent a significant medical morbidity among aged population with osteoporosis recognized measure of scientific impact [ 38 ] is as. In Continuing dental Education www.indiandentalacademy.com 2 total of 177 different authors contributed to the Oral...
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