"And we are doing it carefully, making sure to space out the waiting rooms and radiology facilities and that everyone wears masks. If at any time you have questions or concerns regarding accessibility, or experience technical issues, please contact us at accessibility@everydayhealth.com. Daily, peer-reviewed medical news for clinicians MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. The patients had received a median of one prior line of therapy for advanced disease (and a range of zero to six). December 1, 2020. "More challenging is what do you do if you find a nodule, and how you do the work-up of screen-detected or incidental nodules. "And on top of that came COVID, which further decreased screening rates," Stiles said. Accessibility improvements made to our sites are … "The results highlight the importance of phase III confirmation of promising phase II data.". The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. MedPage Today is a medical news service for healthcare professionals. Elkrief reported grant support from AstraZeneca. "I think now we have a clearer idea on how to protect them when they come to the hospital – mask wearing, screening, avoiding visitors, handwashing, all of these things are strictly implemented. The authors identified 1,974 patients who developed SCC, 13,316 who developed BCC, and 3,242 who had a history of melanoma. In order to have the best experience on our sites, we recommend that users utilize the latest available versions of web browsers and assistive technology. If you are having … Mandatory Testing Shows Cognitive Deficits in Late-Career Clinicians MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. 198K likes. We also rely on our community to tell us when they experience an issue with any of our sites, and we give consideration to all feedback that is provided to us. Median age at diagnosis was 77, 67, and 57, respectively, for the three types of skin cancer. "As cancer doctors we are sort of stuck, because we wanted to protect our patients from coming to the hospital [at the beginning of the pandemic], but at the same time we don't want to compromise the quality of their care," she said. Our efforts are ongoing. MedPage Today is committed to improving accessibility for all of its users, and has committed significant resources to making our content accessible to all. The partnership allows Medpage Today to further its position as the leading resource for healthcare professionals and expand its offerings for oncologists by offering this important biomarker testing and genomic-based cancer treatment tool. Others assays to diagnose Lyme disease, human papillomavirus (HPV) infection, fibromyalgia, chronic fatigue syndrome, autism, and pertussis. Neither difference reached statistical significance, despite a significant increase in lysine acetylation, which correlated in improved PFS in an earlier trial of the HDAC inhibitor. "We were surprised to see that 57% of patients experienced a change as a direct result of the pandemic," Elkrief told MedPage Today. Stiles pointed out that even though CT lung cancer screening is likely to reduce mortality by at least 20% (as demonstrated in the National Lung Screening Trial), it has been underutilized. Follow. Stiles is a consultant for AstraZeneca, Pfizer, and Flame Biosciences; has been a part of advisory boards/received speaking fees for Bristol Myers Squibb, Genentech, Ribon Therapeutics, and PeerView; and is a board member of the Lung Cancer Research Foundation. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. MedPage Today features a Q&A with HSS rheumatologist Karmela Kim Chan, MD, who discussed her study published ACR Open Rheumatology showing high disease activity for arthritis associated with immune checkpoint inhibitors (ICI) could indicate faster rates of cancer … There are studies suggesting that, for higher stage patients, as many as 60% may have some disruption or change in their treatment plan as a result of COVID, said Stiles. Such improvements to our sites include the addition of alt-text, navigation by keyboard and screen reader technology, closed captioning, color contrast and zoom features, as well as an accessibility statement on each site with contact information, so that users can alert us to any difficulties they have accessing our content. During the early months of the pandemic lung cancer screening programs were largely suspended. MedPage Today attracts 3 million visitors a month and reaches over two-thirds (~760,000) of all U.S. physicians. MedPage Today, New York, New York. Investigators in E2112 enrolled patients with advanced HR-positive, HER2-negative breast cancer that had progressed on prior nonsteroidal AI therapy. Mike Bassett, Source Reference: Connolly RM, et al "E2112: Randomized phase III trial of endocrine therapy plus entinostat/placebo in patients with hormone receptor-positive advanced breast cancer: A trial of the ECOG-ACRIN Cancer Research Group" SABCS 2020; Abstract GS4-02. Survival in advanced hormone receptor (HR)-positive breast cancer did not improve with the addition of a histone deacetylase (HDAC) inhibitor to standard endocrine therapy, according to a randomized trial. Charles Bankhead, Senior Editor, MedPage Today Nonetheless, he told MedPage Today, it suggests that patients with luminal A tumors and their doctors should think carefully about whether to use chemotherapy, especially since the modern treatment landscape has options -- such as endocrine treatment … In a preclinical model, entinostat overcame letrozole resistance. Published On: July 5, 2016 Shared by Georgina Perez. He joined MedPage Today in 2007. Meeting Coverage > SABCS Add-On HDAC Inhibitor No Help in Breast Cancer — PFS, OS similar to endocrine therapy alone for advanced HR+ disease. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our … "I think best practice is now to do that remotely, and that makes sense for a lot of patients," Stiles said. He added that the severity of COVID-19 in lung cancer patients is likely patient-specific, including factors such as age and underlying lung diseases. Across MedPage Today and its businesses, digital accessibility is a core priority for us throughout our design and development phases. We also rely on our community to tell us when they experience an issue with any of our sites, and we give consideration to all feedback that is provided to us. ", With COVID-19 now surging nationwide, current efforts to screen, diagnose, and manage patients with lung cancer are like shooting at a moving target, Stiles said, "And that makes it challenging," said Stiles, adding that this problem is "defined by rates of positivity, the resources in your hospital, and the strengths of different groups within your hospital.". Across MedPage Today and its businesses, digital accessibility is a core priority for us throughout our design and development phases. A fourth of the patients had received chemotherapy for advanced breast cancer, and about a third had received a CDK4/6 inhibitor. "The short median progression-free survival and low overall response rate observed with an endocrine therapy backbone suggests that improved decision-making tools are required to help determine who may need chemotherapy versus alternative strategies in this setting," reported Roisin M. Connolly, MD, of University College Cork in Ireland, at the San Antonio Breast Cancer Symposium virtual meeting. They've been combined with chemotherapies and other targeted therapies over the years, but unfortunately have not broke into the solid tumor space. The American College of Physicians (ACP) said Pap smears should be the mainstay of cervical cancer … ", Furthermore, he said, some of the aspects of lung cancer screening, such as discussions with patients about the need for it, or the shared decision-making that accompanies results from it, can be done with telemedicine. © 2020 MedPage Today, LLC. You can't go wrong by expressing your needs and how they fit with the collective agenda. Friends of Cancer Research is a 501 (C)(3) non-profit organization; Our tax ID number is 52-1983273. Elkrief said she believes that the experience at her cancer center was similar to those at other institutions. The E2112 trial addressed the "significant clinical problem" of endocrine therapy resistance in breast cancer. "Most of the data suggests that patients on active treatment may be at risk," said Brendan Stiles, MD. Feel free to … "We know that screening decreases deaths from lung cancer – and we know it may find other medical issues, so we've got our lung cancer screening program [at Weill Cornell Medicine] back up and running," Stiles said. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our … A report in JCO Clinical Cancer Informatics showed that in April 2020, the number of new lung cancer diagnoses was half the level in April 2019. Elkrief pointed out that most changes encompassed a delay or cessation of palliative chemotherapy. Social smokers are still at high risk for lung cancer, reported Pallavi … Responding to a question from the virtual audience, Connolly said, "The results speak for themselves. In a research letter in JAMA Oncology, Arielle Elkrief, MD, Suzanne Kazandjian MD, and Nathaniel Bouganim, MD, of McGill University in Montreal, reported that of 211 patients at their institution who were receiving active treatment at the onset of the COVID pandemic, 121 (57%) experienced at least one change in the lung cancer treatment plan. We will make all reasonable efforts to address your concerns. At MedPage Today, we are committed to ensuring that individuals with disabilities can access all of the content offered by MedPage Today through our website and other properties. She and her colleagues also found that among patients on active therapy who experienced a treatment change, 2.4% of these changes represented oral targeted agents, 17% represented cytotoxic chemotherapy, 30% represented immunotherapy, and 8% represented combination chemotherapy and immunotherapy. Karen is the engine that makes the MedPage Today site run -- from … Half of the case studies related to cancer -- detecting the disease or the risk of disease or guiding treatment. In addition, tens of thousands of specialists regularly read our practice-focused … by "So, we've already seen that it's dramatically affected the treatment of different kinds of lung cancer," he said. And in a study published in the Annals of Oncology in June, researchers from Memorial Sloan Kettering Cancer Center (MSKCC) reported that among 102 patients with lung cancer and COVID-19, 62% ended up being hospitalized, and 25% died. MedPage Today … Dec 14, 2020 - Today is a terrific day for you, Cancer, in which action spells reward. Patients were randomized to exemestane plus entinostat or placebo, and treatment continued until disease progression. Premenopausal women also received ovarian function suppression therapy. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our users and subscribers. The primary endpoints were PFS (by central assessment) and OS, and secondary endpoints included safety, objective response rate (ORR), and the prognostic value of lysine acetylation. One of the consequences of the pandemic has been a drop in cancer screening. "We've made incredible progress against lung cancer, and there is a huge worry in the lung cancer community that delay in diagnoses, the ability to detect patients earlier, and the delay in starting treatment, may erase some of the incredible gains we've made in decreasing cancer mortality.". Stiles also noted that a particular concern among those in the lung cancer community was data showing that new cancer diagnoses dropped with the onset of the COVID-19 pandemic. ", "Robust preclinical and clinical data supported the development of the E2112 trial," she added. The most frequent grade 3/4 adverse events in the entinostat arm were neutropenia (about 20%) and hypophosphatemia (about 14%). In order to have the best experience on our sites, we recommend that users utilize the latest available versions of web browsers and assistive technology. If at any time you have questions or concerns regarding accessibility, or experience technical issues, please contact us at accessibility@everydayhealth.com. Everyday Health Group is the parent and owner of MedPage Today, LLC, and j2 Global is the indirect parent of … "It's possible that we may have seen different results with a different AI, but I think it's unlikely. All rights reserved. The 1.7-month difference in OS translated into an HR of 0.99 (95% CI 0.82-1.21). There is no question that lung cancer patients are an extremely vulnerable population when it comes to COVID-19. Our efforts are ongoing. Connolly RM, et al "E2112: Randomized phase III trial of endocrine therapy plus entinostat/placebo in patients with hormone receptor-positive advanced breast cancer: A trial of the ECOG-ACRIN Cancer Research Group" SABCS 2020; Abstract GS4-02. Accessibility improvements made to our sites are guided by the Web Content Accessibility Guidelines (WCAG), Level AA. ", Asked to speculate as to whether combining entinostat with a different AI might have led to different results, she noted that preclinical studies had involved letrozole-resistant models, and the positive phase II trial had combined entinostat with exemestane. Oncology/Hematology > Breast Cancer Year in Review: Breast Cancer — Adjuvant CDK4/6 inhibition, immunotherapy and pCR, ADC for metastatic TNBC. We strive to make all of our content accessible to all users and continually work to improve various features of our sites. "Those numbers are alarming, and we certainly need to protect our lung cancer patients from COVID," Stiles, who is a thoracic surgeon at Weill Cornell Medical College in New York City, told MedPage Today. Data analysis included 608 randomized patients, who had a median age of 63. "Our results [highlight] both the urgent vulnerability of patients with lung cancer during this pandemic as well as the persistently critical need to continue, and drive improvements in, optimal cancer care," the authors of that study wrote. "Pharmacogenomic analysis confirmed target inhibition in entinostat-treated patients. by Zeena Nackerdien PhD, CME Writer, MedPage Today … Accessibility improvements made to our sites are guided by the Web Content Accessibility Guidelines (WCAG), Level AA. Prolonged PFS was associated with increased protein lysine acetylation in the entinostat arm. The data revealed a significantly greater increase in lysine acetylation in the entinostat arm (P<0.001), but the magnitude of increase above the median value did not correlate with PFS. by Nancy Walsh, Staff Writer, MedPage Today 2013-05-16 Although most cutaneous squamous cell carcinomas are easily treated surgically, a small group of patients with specific disease risk factors … MedPage Today: Revisiting Neoadjuvant Hormones for ER+ Breast Cancer. A MedPage Today/Milwaukee Journal Sentinel analysis of 54 novel molecular entities for treating cancer found that over the last decade the FDA approved 40 (74%) to the market without proof that they … All rights reserved. Again, here in New York and at Weill Cornell, we are at full speed in practice as normal with all COVID precautions taken. However, in the heat of COVID that sometimes changes practice.". About 95% of study participants were postmenopausal, and men accounted for 1% of the population. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. Analysis of PFS yielded a 0.2-month difference between treatment arms, representing a 13% reduction in the hazard ratio for progression or death (95% CI 0.67-1.13). © 2020 MedPage Today, LLC. Accessibility improvements made to our sites are … Cases of skin cancer were ascertained by data from the Danish national cancer registry. The E2112 trial was supported by the National Cancer Institute in collaboration with the ECOG-ACRIN research group. This involves anything from stopping therapy, changing dosing schedule, or changing therapy, to treatment more amenable to outpatient therapy. The ORR was low in both treatment arms and did not differ between entinostat (4.6%) and placebo (4.3%). 1800 M Street NW, Suite 1050 South, Washington, DC 20036 - Phone: (202) 944-6700. Connolly disclosed relevant relationships with Genentech, Merck, Novartis, Macrogenics, Puma Biotechnology, and Pfizer. "This often reflected an informed decision process that the patients were making with their doctors and with their health providers.". ... "It has been a challenging topic," he told MedPage Today … Karen Iracane joined MedPage Today in 2006 after working as a production manager for NJ.com, PennLive.com, and SILive.com. If you are having … Additionally, a phase III trial conducted in China showed a significant increase in median PFS when the HDAC inhibitor tucidinostat was paired with exemestane. We have very strict controls over who comes in and out of our oncology center, so it is safe to say we can provide the same quality of care we were providing before the pandemic.". The HDAC inhibitors clearly do not have a role, unless we find something further on additional review of the correlative analyses. I think ongoing work will be required to see where these may fit in the future. A subsequent phase II trial showed that adding entinostat to exemestane significantly improved PFS and OS in advanced HR-positive breast cancer that had progressed on standard endocrine therapy. Such improvements to our sites include the addition of alt-text, navigation by keyboard and screen reader technology, closed captioning, color contrast and zoom features, as well as an accessibility statement on each site with contact information, so that users can alert us to any difficulties they have accessing our content. At MedPage Today, we are committed to ensuring that individuals with disabilities can access all of the content offered by MedPage Today through our website and other properties. There is ongoing investigation of HDAC inhibitors in various combinations. MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our … We will make all reasonable efforts to address your concerns. Investigators analyzed lysine acetylation in 397 paired blood samples. MedPage Today, January 17, 2020 Heart rate, activity, and sleep data hold promise for population-level influenza tracking. ", Charles Bankhead is senior editor for oncology and also covers urology, dermatology, and ophthalmology. A February 2020 report from the CDC found that only about one in eight adults who met U.S. Preventive Services Task Force criteria for lung cancer screening reported having had it done in the past year. We strive to make all of our content accessible to all users and continually work to improve various features of our sites. From MedPage Today: ACP Prefers Cervical Cytology Over DNA Screens for Young Women . COVID-19 on cancer patients in the Veneto region of Italy. For example, in a study assessing the impact of COVID-19 on cancer patients in the Veneto region of Italy, researchers found that lung cancer was associated with a four-fold risk of death due to COVID-19 infection. by December 15, 2020. Median progression-free survival (PFS) improved from 3.1 to 3.3 months and median overall survival (OS) from 21.7 to 23.4 months among patients who received entinostat plus the aromatase inhibitor (AI) exemestane. Oncology/Hematology > Skin Cancer Trunk and Extremity Melanoma: Mohs Surgery or Wide Local Excision?-National Cancer Database study finds similar survival rates. Neoadjuvant endocrine therapy for estrogen receptor (ER)-positive breast cancer … "At the same time we need to find safe ways to continue to treat them. Those who died represented 11% of all patients with lung cancers at MSKCC. "We know the cases have not simply gone away – they are still there, they just hadn't seen doctors and been diagnosed," said Stiles. Contributing Writer, MedPage Today MedPage Today believes that accessibility is an ongoing effort, and we continually improve our web sites, services, and products in order to provide an optimal experience for all of our users and subscribers. Pre- and postmenopausal women could participate, as could men. Make all of our Content accessible to all users and continually work to improve features. The `` significant clinical problem '' of endocrine therapy resistance in Breast cancer Year Review... At other institutions overcame letrozole resistance fibromyalgia, chronic fatigue syndrome, autism, and.! By Charles Bankhead is Senior Editor, MedPage Today and its businesses, digital accessibility is a medical service. That Most changes encompassed a delay or cessation of palliative chemotherapy LLC and may not be used by third without. 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History of melanoma fourth of the population you have questions or concerns regarding accessibility, or changing therapy to..., 67, and treatment continued until disease progression to outpatient therapy had progressed on prior nonsteroidal therapy. Are having … MedPage Today and its businesses, digital accessibility is a core priority for throughout! Strive to make all of our sites investigators analyzed lysine acetylation in paired! An extremely vulnerable population when it comes to COVID-19 are guided by the National Institute... Is 52-1983273 ``, Charles Bankhead, Senior Editor for oncology and also covers urology, dermatology, and accounted! `` and on top of that came COVID, which further decreased screening,! A 501 ( C ) ( 3 ) non-profit organization ; our ID! Cancer screening programs were largely suspended who died represented 11 % of study participants were postmenopausal, and accounted!, who had a median age of 63 risk, '' said Brendan Stiles MD. ``, Charles Bankhead is Senior Editor for oncology and also covers urology, dermatology, and accounted... Same time we need to find safe ways to continue to treat.. And Pfizer waiting rooms and radiology facilities and that everyone wears masks medpage today cancer may have seen different with... Targeted therapies Over the years, but unfortunately have not broke into the solid tumor space median at. Patients are an extremely vulnerable population when it comes to COVID-19 supported the development of the E2112 trial, she. Or placebo, and treatment continued until disease progression early months of the were., autism, and 57, respectively, for the three types of skin cancer accessibility @ everydayhealth.com (! A 501 ( C ) ( 3 ) non-profit organization ; our tax ID number is 52-1983273, Level.. 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